The Division of Radiation Oncology has a vibrant research program within the unit of molecular and translational radiation biology. Current ongoing research projects encompass research themes in highly aggressive types of cancer including glioblastoma, lung cancer and triple negative breast cancer. The overarching goal is to address important clinical issues related to (i) the efficacy of new drugs in combination with radiation therapy using in vitro and in vivo pre-clinical animal models (ii) resistance to radiation therapy (iii) cellular and biological effects of different modalities of radiation therapy delivery based on the genomic and molecular profile of cancer cells and iv) identification of biomarkers associated with response to radiation therapy and predictive biomarkers of radiation-induced toxicities.

Our research labs are integrated within the Cancer Research Program of the Research Institute of McGill University Health Centre (RI-MUHC). In addition to a CFI-funded equipment for a translational research platform for blood processing and bio-banking, our team members have access to multi-user facilities available at the RI-MUHC (confocal microscopy, flow cytometry, vivarium for in vivo studies using animal models) and will benefit from additional outstanding resources and infrastructure when the MUHC will move its activities to the Glen site in 2015.

Our team members continuously contribute to peer-reviewed publications and presentations at national and international conferences. As a part of our academic mandate, we contribute to mentoring a new generation of graduate students and trainees to translate research findings from in vitro and in vivo pre-clinical studies to fully implementing clinical trials. The main channel for graduate students in our research unit is through the department of experimental medicine at McGill University. We also host medical students for their elective research training, students enrolled within the McGill clinical graduate training program for the practicum training of future clinical research coordinators and undergraduate students for their research summer projects.

Current Research Units include:

Molecular and Translational Oncology Research Unit (PI: Dr Siham Sabri)

Translational Radiobiology Research Unit (PI: Dr Bassam Abdulkarim)